Calm the raging hormone - a new therapeutic strategy involving progesterone-signaling for hemorrhagic CCMs
نویسندگان
چکیده
Cerebral cavernous malformations (CCMs), one of the most common vascular malformations, are characterized by abnormally dilated intracranial microvascular capillaries resulting in increased susceptibility to hemorrhagic stroke. As an autosomal dominant disorder with incomplete penetrance, majority CCMs gene mutation carriers largely asymptomatic, but, when symptoms occur, disease has typically reached stage focal hemorrhage irreversible brain damage, while molecular “trigger” initiating occurrence CCM pathology remain elusive. Currently, invasive neurosurgery removal lesions is only option for treatment, despite recurrence worse frequently occurring after surgery. Therefore, there a grave need identification targets therapeutic treatment and biomarkers as risk predictors stroke prevention. Based on various perturbed angiogenic signaling cascades mediated complex (CSC) reported, have been many proposed candidate drugs, targeting potentially angiogenic-relevant pathways dysregulated loss function proteins, which might not be enough correct pathological phenotype, CCMs. In this review, we describe new paradigm mechanism propose concept assurance CSC stability prevent devastating outcome
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ژورنال
عنوان ژورنال: Vessel plus
سال: 2021
ISSN: ['2574-1209']
DOI: https://doi.org/10.20517/2574-1209.2021.64